1921
Volume 13, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

The response of laboratory-reared and to inoculation with Cocal virus was studied. appears to be the more susceptible. Low-level viremia of short duration was detected in some animals of this species. Regular virus isolations were made from the crusts of superficial skin wounds in inoculated subcutaneously. Of 22 inoculated subcutaneously or intradermally with 8th and 1st mouse brain passage virus, respectively, eight became paralyzed in the hind limbs. Death followed in 1 or 2 days in the four paralyzed animals that were not killed. In all eight animals, the virus content of the spinal cord exceeded that of the brain.

No illness was observed in . Virus could be isolated with some regularity from the crusts of superficial skin wounds in this species only when the virus had been inoculated in the edge of the wound.

Both rodent species appeared to become infected after intradermal inoculation by the multiple pressure method.

Nasal instillation of virus infected both species and produced high mortality in . Virus was recovered from the lungs of two dead .

Both species were refractory to infection by the oral route.

The implications of the results for a further understanding of the epizootiology of Cocal virus infection are discussed.

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/content/journals/10.4269/ajtmh.1964.13.613
1964-07-01
2017-09-23
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