1921
Volume 13, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

The biological disposition of antimony in hamsters and mice infected with and treated with Sb-124 labeled sodium antimony dimercapto-succinate was studied. Single and multiple injection schedules with doses of the drug totaling 150 mg/kg resulted in the highest concentration of antimony in the liver, 182–266 times plasma levels. Twenty-four hours after the third daily injection of 50 mg/kg the concentration of antimony in the female worms was of the same order of magnitude as that in the liver and about three times that in the male worms. In some individual female worms antimony concentration far exceeded that in the liver. After a single intraperitoneal injection of the drug average antimony concentration in female worms steadily increased over a 48-hour period. During the same period blood and tissue levels of antimony fell rapidly. In male worms there was a selective localization of antimony in the testes. Shortly after injection there was a striking concentration of antimony in the eggs deposited in the tissues ranging from 800 to several thousand times plasma antimony levels. Miracidia hatched from these eggs also had concentrated the mineral. The eggs in the intestines contained more antimony than those in the liver. Evidence is presented to suggest that this difference may depend upon differences in egg maturity.

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/content/journals/10.4269/ajtmh.1964.13.558
1964-07-01
2017-09-22
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