Volume 13, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Thirteen chronic stool carriers of were studied to determine the number of typhoid bacilli in stool, gastric juice, and duodenal aspirate before and after intravenous injection of Pancreozymin®. The number of salmonella excreted ranged from 10 to 10 per gram of feces in 42 of 46 specimens from the 13 patients, and only 1 sample was negative for was recovered from the pre-pancreozymin duodenal aspirates of only 6 of the 13 patients. However, after administration of pancreozymin, in titers of 10 to 10 per ml was recovered from the duodenal aspirate of every patient. In 12 of the 13 patients the number of salmonella in the post-pancreozymin specimen exceeded by at least 10-fold the number in the pre-pancreozymin specimen.

The present studies show that chronic typhoid carriers regularly excrete large numbers of in stool. The evidence strongly suggests that the biliary tract is the primary site of multiplication in those patients.


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