1921
Volume 12, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

A purified Colorado tick fever (CTF) vaccine has been prepared from suckling mouse brain by adsorption on calcium phosphate and elution by sodium phosphate. Elution with 0.2 M NaHPO yielded antigenic preparations low in protein and allergic encephalitis-producing properties, yet high in protective potency. Potency and sensitivity tests in man and laboratory animals indicate that safe and effective vaccines against CTF may be produced by this method. Preliminary data suggest that this method of purifying CTF virus may be applicable to other similar viruses.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1963.12.678
1963-07-01
2017-11-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1963.12.678
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error