1921
Volume 12, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

The indirect hemagglutination test and the bentonite flocculation test utilizing a saline extract of have been evaluated. The test was reactive with sera from individuals with infections of and showed higher titers for symptomatic patients with microfilariae in the blood. In a group of 42 symptomatic patients, 92% of 13 microfilariae-positive patients and 62% of 29 microfilariae-negative patients showed positive serologic tests. In a group of 15 asymptomatic individuals with microfilariae in the blood, 67% were positive. From a group of 295 asymptomatic-microfilariae-negative individuals, 21 sera (7%) were positive.

Testing 632 sera from 295 normal missionaries, 84 normal Americans, and 253 individuals with various other parasitic and bacterial infections, an over-all non-specific response of 10% was obtained, utilizing the following criteria for a positive serologic test: (1) a hemagglutination titer of 1:200 or higher with a positive flocculation of 1:5 or higher, or (2) a hemagglutination titer of 1:400 with a negative flocculation reaction. Sera from 141 patients with helminth diseases showed a non-specific rate of 21%. This high rate was due to cross-reactions with trichinosis sera (35%) schistosomiasis (20%) and ascariasis (27%). Since the schistosomiasis and ascariasis sera were from individuals born in an area endemic for filariasis, the reactions may represent a serologic response to past experience with filariasis. Only 5% of 112 sera from individuals with non-helminthic diseases and 5% of 84 sera from normal individuals were positive.

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/content/journals/10.4269/ajtmh.1963.12.548
1963-07-01
2017-11-23
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