1921
Volume 12, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Metronidazole has a potent inhibitory effect upon the multiplication of . It completely inhibits growth of this organism at a concentration of 0.8 micrograms per milliliter.

Infection of the vagina of rats with was induced experimentally after castration and implantation of estradiol.

A dose of 20 mg of metronidazole per kg given by mouth for 5 days resulted in complete disappearance of the organism from the vagina of a small series of rats experimentally infected. Ten mg per kg, which is similar to the dosage used in some human cases in which treatment failures have occurred, similarly resulted in a lower rate of cure in rats.

The use of rats with induced vaginal trichomoniasis seems to be valuable for screening of systemic trichomonacidal agents.

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/content/journals/10.4269/ajtmh.1963.12.535
1963-07-01
2017-09-24
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