1921
Volume 11, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Pyrvinium pamoate (Povan®) removed and from mice when given either in the diet or as a single oral dose. in rats also was readily susceptible to pyrvinium pamoate but and in mice were not. Multiple oral doses efficiently removed ascarids and hookworms in dogs but failed to remove whipworms.

The relationship of these effects to those of pyrvinium chloride is reviewed.

Natural infections in rhesus monkeys were used to assess the antistrongyloides activity of pyrvinium pamoate, while gentian violet, dithiazanine iodide, and pyrvinium chloride were tested as reference drugs. All substances were given orally as aqueous suspensions. Pyrvinium pamoate lacked significant effect under test conditions that permitted varying degrees of effect by the reference drugs. These limited comparisons suggested gentian violet to be the most potent of the drugs tested against simian strongyloidiasis.

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/content/journals/10.4269/ajtmh.1962.11.89
1962-01-01
2017-11-22
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