Volume 11, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Three groups of guinea pigs were inoculated with cultures of or with its associated bacteria: (a) normal, (b) with elevated intestinal cholesterol content, and (c) with hypercholesterolemia. Part of the normal group was inoculated in the cecum and the others in the superior mesenteric vein. The guinea pigs with elevated intestinal cholesterol were inoculated in the cecum while those with hypercholesterolemia were inoculated in the superior mesenteric vein.

The animals which had elevated cholesterol and were inoculated with in the cecum developed larger lesions with greater frequency than did the normal animals.

In the liver, amebic abscesses were found almost exclusively in guinea pigs with hypercholesterolemia, and in these animals the abscesses occasionally were large (1 to 2 cm in diameter) and frequently were numerous.


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