1921
Volume 11, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Twelve attempts at man to man transmission by bites of infected with , seven with the M strain and five with the B strain, were successful. These results suggest that normal, mosquito, transmission of these two strains from man to man can occur with a high degree of frequency.

Observations for the B strain infections were: (1) the prepatent periods ranged from 15 to 20 days (av. 17.6); (2) maximum parasitemia was 150 per cmm of blood; (3) the first day of recorded fever ranged from 15 to 20 days; (4) maximum temperature was 104°F; (5) only one infection began with a tertian fever pattern; and (6) gametocytes were demonstrable in three infections.

Observations for the M strain infections were: (1) the prepatent periods ranged from 16 to 37 days (av. 19.9); (2) maximum parasitemia was 300 per cmm of blood; (3) the first day of recorded fever ranged from 16 to 19 days; (4) maximum temperature was 104.6°F; (5) tertian fever patterns developed in four infections; and (6) gametocytes were demonstrable in three infections.

The predominant symptoms for all infections were cephalgia, anorexia, nausea, and myalgia. Splenomegaly was more frequent and extensive in the M strain infections. Clinical manifestations did not correlate with the degree of parasitemia. The disease syndrome is considered to be mild.

Sporozoite induced M strain infections appeared to be more “virulent” than sporozoite induced B strain infections.

Characteristics of infections induced by blood inoculation of the B strain (5 cases) and the M strain (6 cases) are described.

can become infected when fed on human beings with low gametocyte levels. Relatively few bites of these mosquitoes can produce simian malaria infections in man.

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/content/journals/10.4269/ajtmh.1962.11.186
1962-03-01
2017-11-18
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