1921
Volume 10, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

This study deals with the compound CI-423 [3-chloro-9(4-diethylamino-1-methylbutylamino) acridine, 10-oxide, dihydrochloride] as a potential non-staining, suppressive antimalarial drug.

Comparative testing by the drug-diet method against trophozoite-induced infections in chicks indicated CI-423 to be approximately 16 times as active as quinine, 4 times as active as quinacrine, and one-half as active as amodiaquin.

Comparisons on a single or multiple oral dose basis against trophozoite-induced infections in rhesus monkeys showed CI-423 to be distinctly more potent than either amodiaquin or quinacrine in rapidly suppressing the acute parasitemia and curing the animals.

In contrast to quinacrine, CI-423 did not induce visible staining of the skin of mice or rats when given for respective periods of 2 and 4 weeks.

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/content/journals/10.4269/ajtmh.1961.10.335
1961-05-01
2017-11-22
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