1921
Volume 9, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

The hydroxynaphthoate salt of bephenium was tried 168 times against worm infections in mental patients. Tetrachloroethylene was tried 41 times for comparison.

Bephenium hydroxynaphthoate, in granular form (Alcopara®), exerted good effects against hookworm (). It was more effective than tetrachloroethylene. Dosages of 5.0 grams base single dose daily for 3 or more consecutive days reduced heavy hookworm infections by 95% or more with about 55% of the infections cured. Five-gram doses for 1 or 2 days greatly reduced the hookworm burden but the cure rate was low. The optimum regimen appears to be 5 grams single dose for 3 days or, for mass therapy, a single 5-gram dose.

The drug was highly effective against , giving an over-all egg reduction of over 99%; 12 of 13 infections were eliminated.

Bephenium also was moderately effective against infections. Dosages totaling 15 or more grams resulted in a substantial reduction in worm burden and produced some cures.

Of two known infections treated, neither was cured. A single infection was not eliminated.

Side effects, principally vomiting, occurred in about 7 per cent of the patients. However, in only one patient was it necessary to discontinue treatment.

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