1921
Volume 9, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Studies of the inhibition by various metabolites of the antitoxoplasmic action of pyrimethamine and sulfadiazine in acute mouse toxoplasmosis, alone and in combination, resulted in the following findings:

  • 1.  -Aminobenzoic acid completely antagonized the effect of sulfadiazine and partially antagonized the effect of pyrimethamine. It also partially inhibited the effect of the drugs in combination.
  • 2.  Folic acid incompletely antagonized the effect of sulfadiazine, but did not antagonize the effect of pyrimethamine. It also had no effect upon the drugs when given in combination.
  • 3.  Folinic acid did not materially antagonize the action of the combination of pyrimethamine and sulfadiazine or of the drugs individually.

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/content/journals/10.4269/ajtmh.1960.9.277
1960-05-01
2017-09-25
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