Volume 9, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



  • 1.  A serial intestinal biopsy study of patients with classical epidemic and endemic Asiatic cholera demonstrates that the intestinal epithelium in this disease is intact, contrary to the classical textbook concept that a mucolytic enzyme causes desquamation of the epithelium during life.
  • 2.  The histological abnormalities of the small bowel in cholera revealed an acute enteritis manifested by a mononuclear cell inflammatory exudate, vascular congestion, marked goblet cell hyperplasia with eventual exhaustion atrophy, and increased “turn-over” of epithelial cells. Except in degree, the lesion in cholera could not be differentiated from that in cases of nonspecific diarrhea observed during this epidemic.
  • 3.  The additional finding of a separate, underlying, chronic, atrophic enteritis suggested that a dietary or nutritional factor may be important in predisposing an individual to cholera.
  • 4.  Mucus rather than desquamated cells gives the “rice-water” stool its characteristic appearance.


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