1921
Volume 8, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

This paper presents a study of the pulmonary lesions in the lungs of mice which were infected for a second time with .

The microscopic examinations of the lungs of these superinfected mice were made from 48 hours until 40 days after reinfection. The pulmonary lesions found in the reinfected animals were caused by the disintegration of schistosomulae, followed by obstructive endarteritis and arteriolitis. In the animals sacrificed in the more advanced stages of infection fibrous proliferation of the intimal layer of the small arteries and arterioles with a considerable reduction of the lumen was also observed. Parasites in an advanced stage of autolytic disintegration were seen surrounded by an intensive inflammatory reaction in the arterioles and capillaries.

By comparing these lesions with the lesions observed in the control group, we came to the following conclusions:

  • 1.  There is retention of the schistosomulae in the pulmonary arterial vessels of the premunized mice.
  • 2.  There is high mortality of these retained parasites in different stages of their development, probably due to some unfavorable condition in the pulmonary circulation.
  • 3.  The presence of the dying and dead worms causes the development of endarteritis and arteriolitis.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1959.8.527
1959-09-01
2017-09-25
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1959.8.527
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error