The fourth edition of this handbook maintains and passes the standards of its predecessors. The revision has been extensive. Obsolescent material has been eliminated or reduced and data on, and discussions of, new developments expanded. The latter is particularly true of the material on immunization against viruses.

The book is written for practicing physicians, senior students and other advanced readers desiring a concise summary of important current opinions, practices and data concerning the matters dealt with. It is not a textbook, or reference work for researchers. It deals primarily with the production, standardization, indications pro and con, use, regulation, control, etc., of immunological materials and gives, in concise form, reviews of the underlying principles. It is directed to the British medical reader and uses British practices and experience as a basis for discussion.