1921
Volume 6, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Six different fractions from the venom of were separated out electrophoretically. Eluates of these fractions were tested in mice for lethal, hemorrhagic, neurotoxic and enzymatic activities.

About 80 per cent of the lethal activity of whole venom was concentrated in the A fraction which was dominantly hemorrhagic. Combined eluates of fractions K–A and of A–A were exclusively neurotoxic. Indirect hemolytic activity was strongest in fractions A and A, while egg yolk-inhibitory activity was preponderant in fractions A, A and A.

Specific antiserum (Pasteur Institute) neutralized the hemorrhagic action of whole venom and of fraction A but it had very little activity against the neurotoxic components of the venom. The bearing of these findings on the pathogenesis of snake bite syndrome in human beings is obvious.

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/content/journals/10.4269/ajtmh.1957.6.180
1957-01-01
2017-11-24
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