1921
Volume 5, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

The amino nucleoside of Puromycin was tested for its trypanocidal activity against , and infections in mice and in rabbits. Data reported show that the drug was somewhat effective against only when a small inoculum was used but was highly effective against the other species especially . By treating mice following each of a series of relapses it was not possible to produce true resistance to the drug but it was possible, due to the prolonged course of the infection, to produce changes in the central nervous system of the mouse comparable to those produced by trypanosomiasis in man.

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/content/journals/10.4269/ajtmh.1956.5.504
1956-05-01
2017-09-25
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