Volume 5, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The sensitivity of liquid BCG vaccine to light and temperature complicates its use in mass vaccination campaigns against tuberculosis, especially in tropical regions. Freese-drying applied to BCG gives a more stable product but the vaccine loses some of its viability before becoming stabilized. It still retains high antigenic potency for at least a year in the refrigerator but after two years loses a certain amount. There are many compensating advantages over a liquid vaccine, but dried BCG as prepared at present does not fulfill all conditions for practical application on a large scale since it must be kept at below 5°C. This is the chief problem now under investigation.


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