Volume 4, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Summary and Conclusion

Compound S does not depress the resistance of d b a mice to , but cortisone and hydrocortisone induce acute fatal trypanosomiasis. Whereas cortisone gives rise to marked peripheral parasitemia, and only 11.1% of mice survive more than two weeks, hydrocortisone induces a mild but transient peripheral parasitemia with 45 % of mice surviving longer than two weeks. Compound S does not protect mice infected with against cortisone if the latter is administered within five days, but there is a partial and increasing protection against cortisone as the interval between administration of Compound S and cortisone is increased (9 to 26 days).


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