Volume 4, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Twenty-nine of 371 patients found to have demonstrated in ironhemotoxylin stained preparations, had clinical-laboratory evidence of hepatic involvement. More objective criteria than hitherto used have been found helpful in the detection of hepatitis believed to be due to . Of the twelve tests and signs employed, six were significantly altered in one-third or more of the patients. These abnormalities were corrected on application of erythromycin stearate therapy, as described, in the majority of patients treated.

Twenty-one patients out of 29 treated with erythromycin stearate (one received a combination of erythromycin and fumagillin) showed a favorable response in clearance of their liver disease. In the nine cases resistant to erythromycin therapy, subsequent therapy with chloroquine resulted in a good response in six and equivocal results in two. One patient did not respond to therapy.


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