Volume 3, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The protective effect of North American polyvalent antivenin was tested against the venoms of eight representative species of North American pit vipers. Mice injected with 2 LD of venom were treated by intraperitoneal or subcutaneous injection of 0.1 ml. of antivenin. Significant protection was obtained against the venoms of the San Diego rattlesnake () and the horned rattlesnake (). Questionable protection was obtained against the venoms of the timber rattlesnake () and the massasauga (). No protection was observed against the venoms of the eastern diamondback rattlesnake (), the western diamondback rattlesnake (), the copperhead (), and the water moccasin ( spp.). Intraperitoneal injection of antivenin gave slightly better results than local infiltration of the injured tissue. Antivenin does not prevent local tissue necrosis under these circumstances. Neutralization of the venoms observed here is paraspecific; none of the venoms neutralized are used in the preparation of the antivenin.


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