This volume inaugurates an important new medical monograph series, covering current significant advances in the broad field of elinical medicine, and of the applications of fundamental research to clinical problems. Series I contains contributions ranging from “Talking with the patient” by Steward Wolf, to “Chemical agents used in the treatment of inoperable and far advanced neoplastic disease” by David I. Karnofsky.

Of particular interest to workers in tropical medicine are the following articles: “Prevention of rheumatic fever” by Charles H. Rammelkamp, Jr., and Floyd W. Denny; “Amebiasis” by Henry E. Hamilton; “The present status of the chemotherapy of human malaria” by L. H. Schmidt; “The seasonal arthropod-borne, virus encephalitides” by R. Walter Schlesinger, and “Sickle cell anemia” by Byrd S. Leavell and William A. MacIlwaine.

It is emphasized that the most effective method available for the prevention of initial attacks of acute rheumatic fever is the treatment of the preceding streptococeal infection with either penicillin or aureomycin.