1921
Volume 2, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

The effect of single and multiple doses of pyrimethamine (Daraprim) against blood- and sporozoite-induced infections in chicks was examined. When administered twice daily for 4 days, the maximum tolerated dose for the chick was 0.016 mg./gm.; the minimum effective dose, 0.00002 mg./gm.; the drug was completely prophylactic at 0.00025 mg./gm. and partially prophylactic at 0.00003 mg./gm. When administered as a single dose, the minimum effective dose was 0.00025 mg./gm.; the completely prophylactic dose, 0.004 mg./gm.; and the partially prophylactic dose, 0.0005 mg./gm. When chicks were pretreated with single doses of pyrimethamine, about 50 per cent of the antimalarial activity disappeared per day. Single doses of 0.005 mg./gm. given to chicks with well established sporozoite-induced infections prevented deaths from tissue forms, but doses as high as 0.016 mg./gm. did not cure the infection.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1953.2.771
1953-09-01
2017-11-19
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1953.2.771
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error