1921
Volume 1, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Summary and Conclusions

  • 1.  Fifteen patients with typical acute cases of malaria were treated with chloramphenicol by the oral route. In 13 cases was found; in one was found alone, and two were mixed infections.
  • 2.  The dose varied from 50 mg. to 75 mg. per kilogram of body weight per day. Duration of treatment was 8 days in 13 cases, and 6 days and 10 days respectively in the other two. Further observations will be necessary to determine the minimum effective dose.
  • 3.  Results were positive in all cases. The number of attacks which occurred after beginning of treatment varied from 0 to 5 with an average of 3.4. The parasites disappeared between the second and tenth day of treatment in the cases with . In the infections with only the asexual forms disappeared during this period; the sexual forms persisted and the drug apparently had no action on them.
  • 4.  In the subsequent short period of observation there were no relapses, but we cannot say that these patients have been definitely cured.
  • 5.  The therapeutic value of chloramphenicol in malaria is markedly inferior to that of other drugs in common use.

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