1921
Volume 1, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

Data are given regarding the antimalarial effects against of a naturally occurring alkaloid isolated from sp., and 54 synthetic quinazolones related to the alkaloid.

Sixteen of the synthetic quinazolones were as effective or nearly as effective against in ducks as the naturally occurring alkaloid. Seven had chemotherapeutic indices (mouse/duck) of at least twice that of the naturally occurring alkaloid. The naturally occurring alkaloid was found to be approximately 100 times more effective than quinine against in ducks.

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/content/journals/10.4269/ajtmh.1952.1.768
1952-09-01
2017-09-23
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