Volume 1, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



  • 1.  The New Guinea C and D strains were readily adapted to unweaned mice after a relatively small number of serial intracerebral passages.
  • 2.  Work with dengue virus may be greatly facilitated by using unweaned mice rather than older animals for isolation and passage, and, with certain strains, for neutralization tests.
  • 3.  The 5 strains of dengue virus studied behaved relatively uniformly in unweaned mice 2–6 days of age but differed sharply in their behavior in mice 3–4 weeks old.
  • 4.  Cross-neutralization tests in mice corroborated earlier observations that the New Guinea C and D strains are immunologically different from the Hawaiian and Mochizuki strains.


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