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- The American Society of Tropical Medicine and Hygiene
- Source: The American Journal of Tropical Medicine and Hygiene, Volume 1, Issue 1, 1 Jan 1952, p. 132 - 139
f The in Vitro Activity of Certain Antimalarials against Erythrocytic Forms of Plasmodium Gallinaceum 1
Abstract
Summary
A series of compounds was tested for antimalarial activity in vitro against the erythrocytic forms of Plasmodium gallinaceum. Chloroquine, quinacrine, quinine, and the naphthoquinone, SN 12,320, were active at concentrations approximating those found in the blood of adequately treated chicks. Pamaquine was relatively inactive in vitro, but when administered to chickens gave rise to active metabolic intermediates. Sulfadiazine, metachloridine, chlorguanide, and two of its metabolic intermediates from monkeys, a number of 2,4-diaminopyrimidines, and a 2,4-diaminopterin were relatively inactive in vitro.
© The American Society of Tropical Medicine and Hygiene