Volume s1-30, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A study has been made of the response of some of the more common vertebrates of Brazil to yellow fever virus introduced by the bites of infected mosquitoes. The results obtained are summarized in Table 11.

and failed to circulate virus following such exposure; and either circulated virus only occasionally or in too low concentrations to be epidemiologically significant. circulated virus with sufficient regularity and abundance to be a potential source of infection for blood-sucking arthropod vectors.

and fail to develop neutralizing antibodies following the bites of infected mosquitoes; in and these antibodies appear irregularly or in barely demonstrable concentrations; furthermore, in the first two species mentioned they are not permanent. produces neutralizing antibodies with regularity but they tend to disappear within a few months. Consequently, negative neutralization test results obtained in immunity surveys based on sera from any of these animals are of no value. Positive results obtained with sera from or would, if specific, indicate recent infections; positive results with sera from or might indicate either a recent or an old infection. Complement fixation tests are applicable only to sera from a positive result with sera from this species indicates a recent infection.

Immunity surveys based on the immunological examination of sera from captured wild animals are valid only when it is well established that animals of the species under consideration are capable of forming antibodies with regularity following the bites of infected insect vectors. Consideration must also be given to the length of time during which these antibodies, if formed, persist in a demonstrable concentration in the serum of the infected animal.


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