1921
Volume s1-30, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  An method of testing the amebicidal action of a chemical agent is described in detail. The results of this study show that flask cultures employing the Balamuth medium are very satisfactory for the uniform growth of trophozoites of in large numbers.
  • 2.  Comparative tests on four chemical agents were made. N-Methyl-Emetine-diiodomethylate, a new compound, possesses extremely low amebicidal action . These agents arranged in the order of their amebicidal action are emetine hydrochloride (1 part in 80,000), Iodochloroquine (1 part in 6,000), Chloroquine (1 part in 4,250) and N-Methyl-Emetine-diiodomethylate (1 part in 50).
  • 3.  Only an approximate estimation of the effectiveness of drugs as amebicides can be determined from studies.
  • 4.  N-Methyl-Emetine-diiodomethylate has very little amebicidal activity .

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/content/journals/10.4269/ajtmh.1950.s1-30.59
1950-01-01
2017-09-23
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