1921
Volume s1-30, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary

  • 1.  Ten antibiotics have been studied by Hansen and Bradin , and among these agents, only antibiotic “S” and NA7M10 appear to act against , and not indirectly by inhibition of associated bacteria.
  • 2.  Thirty-one naturally infected macaques were given orally maximum tolerated amounts of antibiotic “S”, aureomycin, actidione, lupulon, subtilin, and a mixture of bacitracin, polymyxin B and streptomycin, as well as NA7M10 subcutaneously.
  • 3.  Aureomycin, in amounts which were eventually lethal, provided temporary clearance of amebas for periods up to 25 days. The mixture of three antibiotics, (bacitracin, polymyxin B and streptomycin), provided immediate cessation of diarrhea, prompt gain in weight and at least temporary clearance of in three of six monkeys given tolerated amounts.
  • 4.  Antibiotic NA7M10, while most active (at 1:5 million dilution) proved to be lethal on subcutaneous injection in four of eight animals when given in doses of 8 mgm. per kilo or more. Lower doses given over 7 days, cleared 2 of 4 macaques of for periods up to 30 days after therapy.
  • 5.  The advantage of the tri-antibiotic mixture, as a possible substitute for emetine, is that it may afford prompt symptomatic relief of diarrhea or dysentery in tolerated dosage. NA7M10 deserves consideration, provided a suitable form for oral use is made available.
  • 6.  The necessity for interpretation of these results, except with aureomycin and NA7M10, as “contact” antibiotic therapy without appreciable systemic effects is emphasized.
  • 7.  Should these studies be pursued in man, it is imperative that a systemically active amebacide be employed subsequently.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1950.s1-30.193
1950-03-01
2017-09-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1950.s1-30.193
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error