1921
Volume s1-30, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  Seven strains of , differing in host-background, geographic distribution, virulence, and history of laboratory propagation were found to be immunologically interrelated. After spontaneous or drug-induced recovery from infection with any one of these strains, mice were immune to repeated challenges with the lethal -strain which killed all non-immunized controls within 13 days.
  • 2.  Mouse antisera to the seven strains agglutinated homologous and herologous cultures of the same species at dilutions up to 1:2400, but did not react with . Some of the antisera also contained lysins of low titer. Normal mouse sera had no agglutinating or lytic properties.
  • 3.  Passive immunization with mouse antisera of high agglutinating titer, or prolonged pre-treatment with formalinized crithidia, blood trypanosomes and lyophilized leishmania stages from infected spleen, did not protect mice significantly against -strain.
  • 4.  The sera of four human Chagas' disease patients at dilutions up to 1:200 agglutinated living (but not killed) cultures of six strains. These cultures differed considerably in their response to the natural agglutinins in normal human sera. The “smooth” -strain was least reactive with normal sera, hence most valuable as a diagnostic test-antigen.
  • 5.  A simple, rapid slide-agglutination routine for the diagnosis of Chagas' disease by means of -strain is described.
  • 6.  Inter-strain immunity, the nature of the protective mechanism and the present status of clinical diagnosis of Chagas' disease are discussed.

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