1921
Volume s1-29, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

The protective properties of aureomycin hydrochloride, sulfamerazine, sodium sulfathiazole or 4,4′-diamino diphenyl sulfone have been demonstrated and compared by oral administration to mice inoculated with toxoplasma.

The sulfone provided a greater degree of protection than any of the others tested. Aureomycin and sulfathiazole afforded approximately equal protection while sulfamerazine was the least effective.

Since para-aminobenzoic acid failed to counteract the protective effect of aureomycin it appears that the mode of action of this antibiotic in preventing the death of toxoplasma-infected mice is different than that of sodium sulfathiazole or 4,4′-diamino diphenyl sulfone.

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/content/journals/10.4269/ajtmh.1949.s1-29.889
1949-11-01
2017-09-22
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