1921
Volume s1-29, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  Thirty-three rabbits (Experiment I) were inoculated intraoesophageally with cultivated cysts of . Of this group of animals, 6, or 18 per cent, contracted intestinal amoebiasis as was demonstrated by the recovery of amoebae from intestinal scrapings and the production of lesions.
  • 2.  Eleven rabbits (Experiment II) were inoculated intracaecally with trophozoites of . Of this group of animals, 10, or 91 per cent, contracted intestinal amoebiasis as was demonstrated by the recovery of amoebae from intestinal scrapings and the production of lesions.
  • 3.  Flask-shaped lesions and “bottle” ulcers were produced in the various animals.
  • 4.  In one rabbit lesions were observed not only in the large intestine but also in all portions of the small intestine.
  • 5.  The severity of the infections varied from those rabbits having a few small lesions to those having numerous small and large lesions. Many of the latter were fulminating cases and the amoebic infection often produced the death of the animal.
  • 6.  Many of the trophozoites of , taken from scrapings of lesions, contained not only erythrocytes, but also numerous bacteria, protozoan flagellates and a fungus.
  • 7.  It seems quite possible that the rabbit may prove to be a most satisfactory experimental animal for immunologic and chemotherapeutic studies in amoebiasis.

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/content/journals/10.4269/ajtmh.1949.s1-29.859
1949-11-01
2017-11-23
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