Volume s1-29, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


In a previous report (1) evidence was presented to show that there is a definite relation between drug activity in the invertebrate host infected with , and drug activity in the sporozoite infected vertebrate host. This conclusion has been predicated on the fact that those drugs which have a prophylactic effect on sporozoite induced infections of in the vertebrate host have a similar prophylactic effect in the mosquito in that they permanently arrest the development of the oocysts so that sporozoites are never produced, whereas, the ordinary suppressive drugs, which have no prophylactic activity in the vertebrate host, are similarly ineffective in the mosquito since they have no discernible effect on the development of oocysts and the production of sporozoites.

For the purposes of this study a prophylactic drug in the vertebrate host is defined as one, which, when administered for a specific interval, permanently interrupts the pre-erythrocytic development of the parasite and prevents the formation of the erythrocytic forms, and, correspondingly, in the invertebrate host, a prophylactic drug is defined as one that is effective against the pre-sporozoite stages of the parasite and prevents the formation of sporozoites.


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