1921
Volume s1-28, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  The hemolysin fraction of cobra venom can be completely eliminated by treatment with alkali.
  • 2.  The determination of the minimal lethal dose of hemolysin showed that it was almost innocuous when administered intra-muscularly into guinea-pigs but was definitely toxic when injected intra-cardially or intra-peritoneally.
  • 3.  Cobra neurotoxin was used for the titration of its corresponding antibody, but the results did not exactly correspond to the protective power of antivenom sera. The anti-hemolysin was linked with the anti-neurotoxin and interefered with the neurotoxin + anti-neurotoxin interaction.
  • 4.  It has, so far, not been found possible to fractionate daboia venom.
  • 5.  Daboia anti-hemolysin titration or modified Nagler's reaction can be used as preliminary tests before the final titration is undertaken.

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