Volume s1-28, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



  • 1.  Six cases of Isospora infection in man have been found in Japan since 1939. Four of them were infected in Japan and the remaining two in China.
  • 2.  Experimental human infection with this parasite was carried on in two volunteers. The symptoms and the courses of infection were quite similar in both cases.
  • 3.  Symptoms were as follows: diarrhoea, abdominal tenderness and distention, nausea, poor appetite, headache and fever.
  • 4.  Fever and diarrhoea began one week after the infection and continued about 10 days. Oocysts appeared in the stool 10 days after the infection and were discharged for a period of more than a month.
  • 5.  Without any treatment, symptoms subsided and the parasite disappeared. That is to say, the life cycle of human Isospora appeared to be self-limited.
  • 6.  A second experimental infection on one volunteer, carried on 33 days after the disappearance of oocysts of the first infection, was not successful.


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