Volume s1-28, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Summary and Conclusions

  • 1.  The efficacy of chloroquine, quinacrine, quinine, and totaquine was tested against 79 induced infections of (USPHS and Trinidad strains).
  • 2.  Chloroquine gave the best results. Quinacrine was better than quinine. Totaquine gave the poorest results.
  • 3.  responded relatively slowly to all the drugs tested. Using similar chloroquine regimens, patients were fully cleared by parasites in the peripheral blood much faster than of , even though the densities of the parasites were several times greater at the beginning of treatment.
  • 4.  No evidence was found that increased amounts of acquired immunity would aid anti-malarial drugs in the faster clearing of the blood stream from parasites.


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