Volume s1-27, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Summary and Conclusions

Field trials in British Guiana in 1946 showed that metachloridine at doses of 1 to 2 grams weekly, divided into 2, 3 or 5 parts, completely suppressed natural infections of and partially suppressed parasitemia with . Limited data indicate good suppression of . No toxicity was seen during the treatment period of 6 months. Lower doses should be tried to determine the minimum effective dose for the suppression of and higher doses should be tried for the same purpose in infections with . The ability of metachloridine to suppress clinical symptoms of infections with should be determined.


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