1921
Volume s1-27, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  The use of radioactive antimony provides a useful tool in the study of the metabolism of the antimonials used in the treatment of tropical diseases.
  • 2.  Following a single intravenous dose of tartar emetic, there is rapid elimination by urine and feces for the first 2 days, followed by a slower and relatively steady rate of elimination for the following 5 days. Approximately 80 percent is eliminated by way of the urine, and 20 percent by the gastro-intestinal tract.
  • 3.  Approximately 12 percent of the antimony is eliminated in 24 hours; 30 percent in a week; and, in one patient, 73 percent of the antimony was eliminated in 4 weeks.
  • 4.  The blood antimony level falls precipitously following injection. There is evidence that the immediate toxic symptoms of antimony therapy are due to injection at a rate too rapid to allow for this drop. The poor results of therapy by infrequent doses may be attributable to the extremely low blood level which persists after a brief interval.
  • 5.  Analogous results of multiple injections in man and the dog suggest that the basic blood level of antimony may be controlled by adjusting the size and frequency of doses.

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/content/journals/10.4269/ajtmh.1947.s1-27.403
1947-05-01
2017-09-23
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