Volume s1-27, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Carrion's disease (Oroya fever, or verruga peruana) is a disease limited geographically to certain ravines and valleys of the Andes Mountains, principally in Peru, to a limited extent in Ecuador and Colombia and possibly in Bolivia and Chile. The causative organism is . According to present knowledge, this organism is transmitted to man by the bite of a night-flying insect, .

There are two phases of clinical importance in this disease. The first phase of the illness may consist of a period of rather mild symptoms, including moderate fever, general malaise, headache and pain in the bones. The patient may make an uneventful recovery from this phase or a very serious illness due to severe anemia may develop. It is believed that the organism directly invades the erythrocytes and eventually causes a rupture of each cell invaded. In the severe anemic form, the organism can be readily identified microscopically on an ordinary blood smear stained with Wright's stain (fig. 1).


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