Volume s1-26, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



  • 1.  In a cholera epidemic, a study of the therapeutic effect of sulfonamide drugs has been made in 25 adult patients treated with sulfaguanidine, 25 with sulfadiazine and 29 without sulfonamides as control.
  • 2.  One death occurred in the control group and one in the group with sulfaguanidine treatment.
  • 3.  The average duration of diarrhea is shortened and the average amount of intravenous saline given is reduced in the sulfonamide-treated group as compared with the control. The differences are statistically significant.
  • 4.  There is no significant difference between the therapeutic results produced by these two sulfonamide drugs.
  • 5.  No striking effect of the sulfonamides on the time of disappearance of cholera vibrios from the stool has been observed.
  • 6.  With the dosage used in this study, only bacteriostatic concentration of the sulfonamides has been found in the stool of the patients under treatment.


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