Volume s1-26, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



were found in the mucous membrane of naturally infected macaques. In all animals examined there were patchy, low-grade, chronic inflammatory reactions and scattered cystic and inflamed crypts of Lieberkühn. The direct relationship of these abnormalities to the presence of the ameba was not positively established, although certainly there seemed to be an invasiveness of a low order. Usually the amebas lying in the tissues were associated with minimal tissue reaction.

The amebas were located only in the mucous membrane layer and from their position would tend to support the idea that they first entered the tissues near the mouth of the cryptal glands where they passed directly into the interglandular papilla of the lamina propria.

On the basis of these pathologic findings, it is our belief that naturally infected monkeys () serve as suitable laboratory animals in the study of proposed amebacides.


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