1921
Volume s1-26, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  Observations on the complete courses of 40 cases of amebiasis among military personnel are reported. There were three asymptomatic “carrier” cases, 28 patients with symptomatic amebic colitis, four with amebic hepatitis, three with hepatic abscess, one with hepatic abscess complicated by diaphragmatic perforation, and one with multiple amebomas of the transverse colon. They were studied under continuous hospitalization for average periods of more than a year.
  • 2.  The clinical findings in general did not vary remarkably from those usually ascribed to the disease. Two features were impressive:
    • a.  The patients' remarkable qualitative constancy of symptoms, including tendency to remission and exacerbation, before treatment and during each relapse.
    • b.  The persistence of colon tenderness and bloodless diarrhea, with negative sigmoidoscopic picture, in cured amebic colitis patients for about two months following completion of successful treatment.
  • 3.  Three amebic colitis patients developed typical chronic idiopathic ulcerative colitis (Bargen's type I) less than two months after cure of amebiasis and after the return of their sigmoidoscopic pictures to essential normality. It is probable that there was no causal relationship.
  • 4.  The patient with multiple amebomas of the transverse colon was studied for 23 months. The static radiologic nature of the tumors over the 20 month period prior to medical eradication of the infection, and their complete disappearance following cure were notable.
  • 5.  The treatment schedules and results are given in detail. Two patients (5 per cent of the series) spontaneously lost their infections without treatment. The other 38 required a total of 62 courses of treatment for cure, as determined by rigid criteria. One case of amebic hepatitis was cured without emetine, and two of liver abscess without surgical procedures.
  • 6.  There was no constant or predictable relationship between the size of drug dose and its effectiveness in amebic colitis.

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/content/journals/10.4269/ajtmh.1946.s1-26.543
1946-09-01
2017-10-21
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