1921
Volume s1-25, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  Protective antibody against yellow fever virus is demonstrable in the serum of rhesus monkeys within 6 or 7 days after inoculation with standard 17D yellow fever vaccine virus.
  • 2.  Rhesus monkeys are completely resistant to the inoculation of highly virulent pantropic yellow fever virus within 5 or 6 days after injection of 17D vaccine. This resistance is present prior to the appearance in the serum of demonstrable protective antibody.
  • 3.  Protective antibody is demonstrable in man in a high per cent of cases by the 10th day after injection of 17D vaccine and may be present as early as the 7th day.
  • 4.  Postvaccination surveys of immunity were made in persons inoculated in Africa with 17D vaccine prepared in New York, and revealed the following:
    • a.  92.2 per cent of military personnel sampled 1 to 22 months after vaccination exhibited protective antibody.
    • b.  90 per cent of civilians inoculated in Kenya exhibited protective antibody in their sera 23 to 36 months after receiving the vaccine.
    • c.  More than 90 per cent of persons vaccinated in Uganda had protective sera after 3 years, and there was no decline in the incidence of immunity during the third year.
    • d.  The percentage of children who became immune as the result of inoculation was as great as that in adults, and the antibody response was equally well maintained.

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/content/journals/10.4269/ajtmh.1945.s1-25.217
1945-05-01
2017-11-18
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1945.s1-25.217
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  • Received : 11 Apr 1945

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