1921
Volume s1-25, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Summary and Conclusions

  • 1.  Dogs naturally infected with were treated with single intravenous injections of tartar emetic, sodium antimonyl xylitol, and an aqueous suspension of antimony trioxide each prepared from radioactive antimony. Animals were sacrificed 36 hours after the injection.
  • 2.  Quantitative estimations of the antimony present in the blood after the injection of tartar emetic and sodium antimonyl xylitol showed that there was an initial rapid decrease of the element in the blood during the first hour followed by a slow removal for the next 4 to 16 hours. In some cases, there was a slight secondary rise in the blood level at 24 or 36 hours.
  • 3.  Following the injection of tartar emetic, examination of the dry tissues from 22 organs revealed that the liver contained the largest amount of antimony. The combined thyroid and parathyroid tissues contained the next largest amount. The adult ranked third in antimony content. It is possible that these tissues have a specific affinity for antimony since their antimony content was considerably greater than could be expected as the result of a simple distribution of a soluble compound throughout body fluids.
  • 4.  The concentration of antimony in the dermal and lymphatic tissues was of very low degree. However, other compounds are under trial and it is possible that one or more of them will be found in greater concentration in these tissues and will thus offer more promise in the treatment of such diseases as the filariases caused by spp. and .

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1945.s1-25.103
1945-03-01
2017-09-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1945.s1-25.103
Loading
  • Received : 19 Dec 1944

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error