Volume s1-24, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



  • 1.  This is a report on the early lesions of acute filarial lymphadenitis and lymphangitis, due presumably to .
  • 2.  Material was obtained by diagnostic biopsy on 17 otherwise healthy young white men who had resided in the islands for 4 months and were exposed to the bites of mosquitoes harboring the non-periodic form of .
  • 3.  The clinical manifestations included acute epididymitis, acute transient retrograde lymphangitis and lymphadenopathy especially of the upper extremities. Intradermal tests were positive in all but one case. Microfilariae were not demonstrated in the peripheral blood during their stay in the hospital and elephantiasis did not occur.
  • 4.  Adult male and female filarial worms were found in five of the specimens. Both living and dead worms were present and the females contained in their uteri large numbers of eggs and microfilariae which appeared morphologically mature. No free microfilariae were found in the tissues.
  • 5.  Cultures of the biopsies, as well as tissue sections specially stained for bacteria, were negative, indicating that the lesions were due to the worms and not to bacteria.
  • 6.  The tissue reactions in the nodes consisted of graulomatous inflammation with marked hyperplasia of the macrophage (reticulo-endothelial) system and tissue eosinophilia. The lymphatic vessels showed reticulo-endothelial hyperplasia, lymph thrombi, and varying degrees of inflammation with or without thrombosis.
  • 7.  It is suggested that the absence of microfilariae from the blood may be due to the avascular nature of the granulomas, the hyperplasia of macrophages, and the small numbers of worms found in the specimens.
  • 8.  The history of these patients proves that white persons can be infected during short visits to endemic areas, and that signs and symptoms of filariasis may develop as early as 3 months after the first exposure to infected mosquitoes.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...

  • Received : 13 May 1944
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error