Volume s1-23, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Summary and Conclusions

  • 1.  Phenothiazine is an effective drug in the treatment of human infection. The drug has been given safely and successfully without noteworthy toxicity to more than 200 patients with this infection.
  • 2.  It is suggested that therapeutic doses be computed on the basis of body weight. A total dose of 300 mg./kg. of body weight administered during three days is suggested for further clinical trial. On this basis children 2–5 years of age are given up to a total of 5 grams; children 6–8 years 7.5 grams; and patients 9–13 years 10 grams; adults may be given 15 grams.
  • 3.  For the present its use should be limited to special clinical investigation, or to patients intolerant or refractory to gentian violet.
  • 4.  Phenothiazine, especially in large doses, is potentially toxic. Manifestations of poisoning are chiefly in the form of hemolytic anemia of various degrees and hepatitis.
  • 5.  Phenothiazine was found ineffective against infections with , and .


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  • Received : 15 Dec 1942

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