1921
Volume s1-21, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Summary

  • 1.  Tests were made in rats on the sensitivity to tryparsamide of 23 strains of trypanosomes () from untreated patients with sleeping sickness and of 5 strains from 4 patients who had received repeated courses of tryparsamide.
  • 2.  The minimum effective dose for the strains from untreated patients was 25 to 50 mgm. per 100 gram rat; that for the strains from 3 treated patients was 50, 100, and 200, mgm. respectively. In a fourth patient who relapsed after one course of tryparsamide the M.E.D. of the trypanosomes was ?200 mgm.; he received a second course of tryparsamide but relapsed again, and the M.E.D. of the trypanosomes on the second occasion was 400 mgm, strongly suggesting that the organisms had acquired an increased arsenic-resistance during the treatment.
  • 3.  These results show that the trypanosomes of patients who relapse after tryparsamide have a greater resistance than normal; but this resistance is not so great as that which can be obtained in the trypanosomes of laboratory animals.
  • 4.  In view of this increased resistance, a second course of tryparsamide is not likely to benefit patients with Rhodesian sleeping sickness who have relapsed after the first course; it is however quite likely to cause blindness.
  • 5.  Trypanosomes from patients relapsing after treatment with Bayer 205 showed no increase of resistance to this compound.

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/content/journals/10.4269/ajtmh.1941.s1-21.469
1941-05-01
2017-09-23
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  • Received : 10 Jul 1940

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