Volume s1-20, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


In 1759 William Hillary (1) described a chronic type of diarrhea associated with sore tongue, pallor and emaciation which he had observed in Barbadoes. A century later in 1864, Julien (2) stated that Cochin-China diarrhea was a specific condition different from ordinary dysenteries and diarrheas. In 1880 Manson (3) in Amoy, and Van der Burg (4) in Java described more fully the features of the disease that Hillary had observed. Since then sprue has been accepted as a peculiar tropical disease and described by many authors.

But although the clinical features of the disease are now so well known, there has never been any agreement as to its precise causation, and many of the earlier theories are completely discredited. The most prominent of these was moniliasis, but Ashford (5) the main protagonist of this theory, in later years regarded sprue as primarily caused by nutritional imbalance complicated by monilia infection.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...

  • Received : 21 Nov 1939

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error