Volume s1-18, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Summary and Conclusions

  • 1.  The basis for chemoprophylaxis of malaria with atabrine is presented.
  • 2.  The results achieved by other investigators are briefly reviewed.
  • 3.  The factors which may influence the relative effectiveness of antimalarial drugs are outlined.
  • 4.  The results of experiments to control malaria by daily prophylactic doses of 50 mgm. of atabrine in the Harris Neck region of Georgia in 1937 are reported, with a brief summary of the similar experience during the previous two years.
  • 5.  The rôle of atabrine in the achievement of success is evaluated.
  • 6.  The reduction of malaria morbidity by prophylaxis with atabrine was not dependent on a fall of malarial intensity (or the ‘down’ curve of a malarial cycle) nor on meteorologic conditions.
  • 7.  The results have been so encouraging that a further trial is warranted; consequently, a fourth year's work has been undertaken and will be reported subsequently.
  • 8.  No untoward reactions or toxic symptoms due to atabrine were observed although many individuals received as much as 25 grams of atabrine over the three year period.


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  • Received : 08 Aug 1938
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